[DeTomaso] Any negative (other than price) in bigger injectors?

[Ken Green]

I'm shopping injectors and need to pick the flow rate.  Does anyone know if there is a down side to bigger injectors or using low impedance injectors if the ECU can drive them?
 
It seems like a bigger injector with a shorter on time (duty cycle), and a low impedance injector that turns on quicker, would take greater advantage of a timed sequential system?
 
I looked at a lot of injector intakes, and the LS-9 points the injectors at the opposite wall, not towards the intake valve.  I think other LS motors point more towards the valve.
 
Regarding injector placement along the intake runner, seems like closer to the head makes it less likely that reversion would push fuel into the plenum and would therefore better tolerate cam overlap?  But closer to the plenum might otherwise be better?
 
You can ask 10 "experts" and you get 10 different answers.  
 
Ken